【作者】 杨巧莲； 张茂林； 张俊清； 张红宇； 郑俊婷；

【Author】 YAiNG qiao-lian ZHANGmuo-lin LIU dan et al.(The First Affiliated Hospital of Inner- mongolia University of Science and Techenoligy ,Neimengolia 014010,China)

【机构】 内蒙科技大学第一附属医院神经内科；

【摘要】 目的探讨脑梗死患者血清谷氨酸(Glu)、一氧化氮(NO)和超氧化物歧化酶(SOD)含量的动态变化及临床意义。方法采用硝酸还原酶法、黄嘌呤氧化酶法及高效液相色谱分析法对30例急性脑梗死患者在起病后一天、三天、七天、十四天连续检测Glu、NO和SOD浓度。结果与正常对照组相比,脑梗死组在病程一天、三天、七天三个时间点上血清Glu水平明显增高(P<0.05),SOD水平明显减低,至第十四天,血清Glu水平接近正常水平,SOD水平仍低于正常。血清NO水平在病程第一天略低于正常水平,但无统计学意义(P>0.05)。在病程第三天、第七天升高(P<0.05),至第十四天,接近正常水平。血清Glu水平、NO水平在病程第三天升高最明显(P<0.05),SOD水平在病程第七天为低谷值(P<0.05)。血清Glu水平与NO水平呈正相关,r=0.371,P<0.001。Glu水平与SOD水平、NO水平与SOD水平呈负相关,r=-0.451,P<0.001、r=-0.262,P<0.001。结论缺血性脑损伤的病理生理过程涉及多个环节,Glu、NO和SOD此过程中起重要作用,Glu、NO与缺血性损伤及再灌流损伤有关,SOD有清除自由基的作用,起脑保护作用。更多还原

【Abstract】 Objective:To study the dynamic changes ofglutamate(Glu)、nitric oxide(NO) and superoxide dismutase(SOD) in blood serum in patients with cerebral infarction, and to probe its clinical significance. Methods: The methods of nitrate reductase、xanthine oxidase and high performance liquid chromatography were used to detect the levels of Glu、NO and SOD in blood serum.Samples were taken from 30 patients with acute cerebral infarction on days 1,3,7and 14. Results:Compared with normal control ,the levels of Glu were increased and SOD were decreased significantly on days 1、3 and 7, and NO were elevated significantly on days 3 and 7.The levels of Glu and NO were sharply enhanced on days 3d,and SOD were the lowest on 7d (P<0.05).On 14d,Glu and NO tended to normal control.So the levels of Glu and NO were positively correlated(r=0.371,P<0.001);and Glu、NO and SOD were negatively correlated(r=-0.451,P<0.001).Conclusion: Glu、NO and SOD play important roles in the whole process of cerebral infarction,Glu and NO relate to the change of ischemia-reperfusion injury,however SOD protects the encephalon from free radicals.更多还原