【作者】 祝成亮； 刘芳； 周新；

【机构】 武汉大学医学院医学检验系中南医院检验科；

【摘要】 目的探讨丙二酰二醛修饰的低密度脂蛋白(MDA—LDL)与冠心病及其它血脂之间的关系。方法选择冠心病患者组68例,正常对照组74例。采用酶联免疫吸附分析(ELISA)的方法检测人血清中MDA—LDL,同时对受检者的血脂水平进行检测,结果进行统计学分析。结果冠心病患者ox-LDL明显高于正常对照组(P<0.01);MDA—LDL与低密度脂蛋白胆固醇之间的水平(LDL-C)之间的比值在冠心病患者明显高于正常对照组(P<0.01)。血清总胆固醇(TG)、LDL—C与MDA-LDL水平呈显著正相关(P<0.01),而高密度脂蛋白胆固醇(HDL-C)与MDA-LDL水平呈负相关(P<0.05)。结论MDA-LDL与冠心病有着非常密切的关系,参与冠心病的发生发展过程。更多还原

【Abstract】 Objective To investigate the correlation between blood lipids like malondialdehyde -modified low - density lipoprotein ( MDA - LDL) and coronary heart disease. Method 68 coronary heart disease patients plus 74 healthy controls were randomly chosen, and ELISA was used to determine serum MDA - LDL levels. Blood lipid levels were also determined. All results were subjected to statistical analysis. Result Ox - LDL were significantly higher in coronary heart disease group than in healthy controls ( P < 0. 05 ) ; the ratio of MDA - LDL to LDL - C were also significantly higher in coronary heart disease group than in healthy controls ( P < 0. 05). TG, LDL - C and MDA - LDL were correlated (P <0. 01), while HDL - C and MDA - LDL were inversely correlated (P <0. 01). Conclusion MDA - LDL were correlated with coronary heart disease, and may take part in the pathogenesis of coronary heart disease.更多还原