【作者】 钱士匀； 陈志斌； 涂蓉； 蔡美华；

【Author】 QIAN Shiyun, CHEN Zhibin, TU Rong, et, al.The Affiliated Hospital of Hainan medical College, Haikou 570102

【机构】 海南医学院附属医院检验科；

【摘要】 为研究脑白质疏松症患者载脂蛋白E基因与血脂水平的关系,选择海南地区50例脑白质疏松症患者和匹配健康人108例进行病例对照研究。采用聚合酶链反应一限制片段长度多态性(PCR-RFLP)技术,检测载脂蛋白E基因多态性并进行基因型分析和血脂水平测定。结果显示脑白质疏松症患者ApoE2等位基因频率为0.15,明显高于对照组的0.074(P<0.05);含ApoE2等位基因患者的甘油三酯、低密度脂蛋白;载脂蛋白B的含量均高于ApoE3等位基因患者。载脂蛋白E2等位基因可能是脑白质疏松症的一种遗传易感因子,ApoE基因多态性可能通过影响血脂水平而影响脑白质疏松症的发生。更多还原

【Abstract】 Objective To study the relationship between polymorphisms of apolipoprotein E gene and serum lipids in leukoaraiosis patients. Methods The polymerase chain reaction - restriction fragment length polymorphism (PCR - RFLP) technique were used to detect apoE genotype in 50 leukoaraiosis patients and 108 control group and serum lipids levels were detected also . Result The frequency of apo E2 allele in the leukoaraiosis group was significantly higher than that in the control group (P <0. 05) . The levels of TG,LDL - c and ApoB in leukoaraiosis patient’s the ApoE2 group was significantly higher that in the ApoE3 group. Conclusion Allele ApoE2 seemed to be a genetic susceptible factor for leukoaraiosis. ApoE gene polymorphism maybe related to leukoaraiosis by affecting serum lipids levels.更多还原