【作者】 宋昊； 郭本玉； 陈佐明；

【Author】 Song Hao,Guo Benyu,Chen Zuoming(The second affiliated hospital of Xinxiang medical college,Xinxiang 453002 ,Henan,China)

【机构】 新乡医学院第二附属医院；

【摘要】 目的评价西酞普兰治疗首发抑郁症的疗效与不良反应。方法将入组的89例抑郁症患者按投币法随机分为西酞普兰组43例和氟西汀组46例。西酞普兰起始剂量10mg·d-1,1w加至20mg·d-1,氟西汀起始剂量为10mg·d-1,1w加至20mg·d-1,共观察6w。两组分别在治疗前和治疗后2、4、6w末采用汉密顿抑郁量表及副作用评定量表(TESS)评定疗效和安全性。结果西酞普兰与氟西汀对首发抑郁症均有确切的疗效,西酞普兰有效率95.32%,氟西汀有效率93.49%,两组疗效无显著性差异。两组副反应均少而轻,差异无显著性。结论西酞普兰是一种安全、有效的抗抑郁药物。更多还原

【Abstract】 Objective To evaluate the curative effects and adverse reactions of citalopram in first-episode depression. Methods 89 patients with depression were randomly assigned to citalpram(n = 43, from 10mg/d to 20mg/d within one week) and fluoxetine(n=46,from 10mg/d to 20mg/d) groups for 6 weeks. The curative effects and adverse reactions of both the two groups were rated with the HAMD and TESS before treatment and at ends the of 2nd, 4th and 6th week of treatment. Results Both citalopram and f uxitine had clear curative effects, the effective rates were 95. 32% and 93. 49% respectively, which showed no significant difference . The adverse reactions of both groups were fewer and milder. Conclusion Xitalopram is a safe and effective antidepressant.更多还原