【作者】 胡晓春； 陈建芳；

【Author】 HU Xiao-chun, CHEN Jian-fang.(School of Stomatology,Jilin University. Changchun 130041,Jilin Province,China)

【机构】 吉林大学口腔医学院牙体牙髓病科；

【摘要】 目的:探讨基质金属蛋白酶-8(MMP-8)mRNA表达与根尖肉芽肿的关系及意义。方法:采用半定量逆转录聚合酶链反应(RT-PCR)方法,检测22例根尖肉芽肿和10例正常根尖组织基质金属蛋白酶-8mRNA的表达。结果:根尖肉芽肿组表达的阳性率高于正常组织组(P<0．05)。根尖肉芽肿的MMP-8mRNA的表达水平高于正常组(P<0．05)。结论:基质金属蛋白酶-8的表达与根尖肉芽肿的发病机制有关。更多还原

【Abstract】 PURPOSE: To investigate the expression of matrix metalloproteinase-8(MMP-8) mRNA in apieal granuloma. Methords: Semi-quantitative reverse transcription polymerase chain reaction(RT-PCR) technique was used to measure the expression of MMP-8 mRNA in the clinical specimens. RESULTS: The positive rates and semi-quantitative level of MMP-8mRNA were significantly higher in apical granulomas than those in normal tissue (P<0.05). CONCLUSION: MMP-8 may play an important role in the pathogenesy of apical granuloma.更多还原