【作者】 杨凯； 李雅东； 张福军； 陈睿； 张劲松；

【Author】 YANG Kai, LI ya-dong, ZHANF Fu-jun , at al. Department of Oral and Maxillofacial Surgery, The first Affiliated Hospital, Chongqing university of medical Sciences, Chongqing 400016, China

【机构】 重庆医科大学附属第一医院口腔颌面外科；

【摘要】 <正>目的: 探讨新辅助化疗对口腔鳞癌患者生存率和生存质量的影响。方法:132例T3、T4口腔鳞癌患者随机分为2组: Ⅰ组(单纯手术)75例:Ⅱ组(新辅助化疗+手术)57例,应用SPSS10．0软件统计分析两组5年生存率和用华盛顿大学生存质量问卷评价两组患者的生存质量。结果:①Ⅰ组和Ⅱ组的5 年生存率分别为42．8％、55．8％,两组间有显著性差异(P<0．05);新辅助化疗有效者和无效者5年生存更多还原

【Abstract】 Objective To investigate the effects of neoadjuvant chemotherapy(NACT) on survival rate and quality of life (QOL) of the patients with Oral squamous cell carcinoma (OSCC). Methods 132 patients with T3 and T4 OSCC were divided randomly into two groups: group I (surgery) VScases; group II (NACT + surgery) 57cases. 5-year survival rate of different groups were analyzed by SPSS 10.0 statistic software, UW-QOL questionnaire was used to evaluate QOL of different groups. Results CDs-year survival rate of group I and group II were 42.8% and 55.8% respectively (P < 0.05 ); 5-year survival rate of the patients who was response to NACT and was non-response to NACT were 66.5% and 45.9% respectively ( P < 0.05 ); 5-year survival rate of the patients who was non-response to NACT and group I were 45.9% and 42.8% respectively ( P > 0.05 ) . (2) QOL of group II was significantly higher than that of group I (P < 0,05); QOL of the patients who was response to NACT was significantly higher than that of the patients who was non-response to NACT ( P < 0.05 ) ; QOL were no significant statistical difference between group I and the patients who was non-response to NACT ( P > 0.05 ) . Conclusion Effective neoadjuvant chemotherapy can improve survival rate and quality of life of the patients with Oral squamous cell carcinoma.更多还原