【作者】 王丽琴； 王小平； 张军；

【Author】 WANG Li-qing,WANG Xiao-ping,ZHANG Jun.(College of Stomatology,Tongji University. Shanghai 200072, China)

【机构】 同济大学附属口腔医院；

【摘要】 目的:探讨稀土化合物氯化镧对人牙龈成纤维细胞(HGF)分泌INF-α的影响。方法:原代培养HGF,用脂多糖进行诱导,采用ELASE法检测氯化镧对脂多糖诱导的HGF分泌TNF-α的影响。结果:含氯化镧组HGF虽经脂多糖诱导,TNF-α分泌量显著低于单用脂多糖诱导组(P<0.05)。结论:氯化镧具有降低脂多糖毒性,抑制HGF分泌TNF-α的作用。更多还原

【Abstract】 PURPOSE: To explore the influence of lanthanum lanthanum chloride on TNF-α secretion of human gingival fibroblast (HGF) induced by LPS . METHODS: Human gingival fibroblast was cultured by block methods. ELASE was used to analyse the secretion of TNF-a. RESULTS: ELASE indicated a significant inhibition of LaCl3 at 1×10-4-1×10-6 mol/L on TNF-a secretion of HGF induced by LPS. CONCLUSIONS: The results suggested that there are some possible relevance of the inhibition of LaCl3 on the release of inflammatory cytokines with its resistance against inflammation .更多还原