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1023中药制剂对实验性癌前损害癌变的阻断及机制研究
Study of the effect and mechanism of Chinese herb medicine 1023 Co. blocking cancer transformation of experimental precancerous lesion
【Author】 CHEN Zuo-liang, GUAN Yu-qin, CHEN Xi, CHEN Xiao-ling, CHEN Jin-chun. (Xiamen Stomatology Hospital. Xiamen 361000, Fujian Province, China)
【机构】 厦门市口腔医院；
【摘要】 目的:探讨1023中药制剂对口腔癌前损害癌变的阻断作用和作用机制。方法:用1023中药制剂(由黄芪、绞股蓝、川芎和含硒绿茶组成),对仓鼠颊囊实验性口腔癌前损害进行为期6周的治疗,观察其对癌变过程的阻断作用,并对1023的活检组织进行2种凝集素受体的测定。结果:1023中药制剂用药组的仓鼠癌变率与对照组相比,下降了30%(P<0.05)。1023用药组的2种凝集素受体表达与未用药的阴性对照组有显著差异。结论:1023有阻止不典型增生癌变的作用,而且有一定的治疗作用。其作用机制可能是1023能诱导或逆转癌前损害向正常分化,并恢复其接触抑制功能。
【Abstract】 OBJECTIVE: To look for a kind of medicine to prevent cancer-transformation of oral precancerous lesion. METHODS: Experimental oral precancerous lesion in hamster cheek pouch was treated with 1023 Co. ( consisting of Astragalus monholicus, gynostemma pentaphyllum, ligusticam wallichii Franch, and green tea ) for 6 weeks, and its role in blocking cancer-transformation was observed, 2 kinds of agglutinin receptors were detected in the biopsies tissues. RESULTS: The rate of cancer-transformation in 1023 Co. group decreased by 30% compared with the control group (P<0.05). Agglutinin receptor in two groups were significantly different. CONCLUSION: 1023 Co. is effective in treating hyperplasia, can prevent its cancer-transformation. The mechanism may be that 1023 Co. can induce precancerous lesions to differentiate to normal tissues.
【Key words】 Chinese herb medicine 1023 co.； Precancerous lesion； Blocking of cancer-transformations； Agglu-tinin receptor；
- 【会议录名称】 中华口腔医学会第六届全国口腔黏膜病学术会议论文集
- 【会议名称】中华口腔医学会第六届全国口腔黏膜病学术会
- 【会议时间】2004-10
- 【会议地点】中国上海
- 【分类号】R739.8
- 【主办单位】上海第二医科大学口腔医学院、上海市口腔医学会