【作者】 高文信； 魏秀峰； 李晓丽；

【Author】 GAO Wen-xin, WEI Xiu-feng,LI Xiao-li. (Stomatology School of Jilin University. Changchun 130041,Jilin Province, China)

【机构】 吉林大学口腔学院；

【摘要】 目的:探讨β-连接素与金黄地鼠颊囊癌变的关系。方法:用免疫组织化学方法检测β-连接素在29例鳞癌,22例异常增生,22例单纯增生及23例正常金黄地鼠颊囊黏膜中的表达。结果:正常金黄地鼠颊囊黏膜上皮细胞全部表达β-连接素,异常增生上皮组织中β-连接素的表达率为81.8%,鳞癌组织中的表达率是44.8%,显著低于异常增生组和正常黏膜组(P<0.01)。结论:β-连接素的表达与金黄地鼠颊囊癌变有相关性,可作为预测口腔黏膜癌变的有价值的指标。更多还原

【Abstract】 OBJECTIVE: To detect the relationships between the expression of β-catenin and the carcinogenesis in golden hamster check pouch. METHODS: The β-catenin expression was examined immunohistochemically in 29 cases of squamous cell carcinoma, 22 cases of dysplasia, 22 cases of hyperplasia, 23 cases of normal epithelium. RESULTS: Strong pericellular staining was showed in the basal, suprabasal and prickle cell layers of normal buc-cal epithelium. Positive rate was 81.8% in dysplastic epithelium, 44.8% in squamous cell carcinoma. CONCLUSION: β-catenin expression was correlated to carcinogenesis of golden hamster check pouch, which may serve as a valuable biomarker for supervising oral malignancy.更多还原