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TGF-β1在口腔颌面部恶性肿瘤中表达水平的研究
Evaluation of TGF-β1 Expression by Oral and Maxillofacial Malignant Neoplasm
【Author】 Li Qing Zhou Xiaojian Zhang Zhiyuan Patima Chen Wantao Dept. of Oral & Maxillofacial Surgery, School of Stomatology, Shanghai Second Medical University
【机构】 上海第二医科大学附属第九人民医院口腔医学院口腔颌面外科;
【摘要】 <正>目的:探讨转化生长因子β1(TGF-β1)在人口腔颌面部恶性肿瘤细胞中表达水平与其生物学行为的关系。方法:以ELISA法分别检测人口腔颌面部手术切除恶性肿瘤组织细胞、人舌鳞状细胞癌细胞系Tca8113、人涎腺腺样囊性癌细胞系ACC-2和人高转移性涎腺腺样囊性癌细胞系ACC-M, 及正常口腔粘膜与粘膜下组织细胞各样本的TGF-β1的表达水平。结果:口腔颌面部恶性肿瘤组
【Abstract】 Objective: To investigate the relationship between the level of transforming growth factor beta Ⅰ (TGF- β1) in oral and maxillofacial malignant neoplasm and the biological characteristics of these carcinoma cells. Method: The level of TGF- β1 in the carcinoma tissue cells, human squamous cell carcinoma cell line Tca8113, human minor salivary gland carcinoma cell line ACC-2 and highly metastatic adenoid cystocarcinoma cell line ACC-M was measured by ELISA KIT. Results: The level of TGF-β1 in the carcinoma tissue cells had significant difference to that of normal cells (P<0.01). The level in Tca8113 and ACC-2 cells was significantly higher (P<0.05). Squamous cell carcinoma cell line Tca8113 had the same level of TGF- β1 as the adenoid cystocarcinoma cell line ACC-2. But the highly metastatic adenoid cystocarcinoma cells (ACC-M) expressed far less compared to ACC-2 cells (P<0.01). The level of TGF- β1 secreted by ACC-M cells to culture without serum was also lower than that of any of the other carcinoma cells or normal cells. Conclusion: The level of TGF- β1 expression had significant relation to the proliferation, infiltration and metastasis of oral and maxillofacial malignant neoplasm.
- 【会议录名称】 第一届全国口腔颌面部肿瘤学术会议论文汇编
- 【会议名称】第一届全国口腔颌面部肿瘤学术会议
- 【会议时间】2001-10
- 【会议地点】中国四川成都
- 【分类号】R739.8
- 【主办单位】中华口腔医学会口腔颌面外科专委会