【作者】 陈万涛； 周晓健； 郭伟； 徐骎； 李卿；

【Author】 Wantao Chen Xiaojian Zhou Wei Guo Qin Xu Qin Li Department of Oral and Maxillofacial Surgery, Affiliated Ninth People’s Hospital, Shanghai Second Medical University

【机构】 上海第二医科大学附属第九人民医院口腔颌面外科；

【摘要】 <正>目的:VM-26是一种植物碱类化疗药物,临床上VM-26已在治疗血液、神经系统恶性肿瘤中取得了好的评效。本研究设计的目的是探讨该药对口腔鳞癌的体外抗肿瘤效果,从而为应用VM-26 治疗口腔鳞癌提供实验依据。材料和方法:取1999年10月～2001年6月上海第二医科大学附属第九人民医院口腔颌面外科住院病人75例纳入研究,75例病人按UICC标准的TNM分期结果为:Ⅰ更多还原

【Abstract】 Objective: Teniposide is one antitumor drug of vegetable-base. It has exerted clinically antiprolierative effect on blood and nervous malignances. The present study was designed to investigate the antitumor effectiveness of teniposide in oral squamous cell carcinoms (OSCC) and to produce evidence for using teniposide to treat the patients with OSCC. Material and methods: Seventy-five patients with OSCC were entered in this study obtained from Shanghai 9th People’s Hospital patients October 1999 to June 2001. Tumors specimens were taken for diagnostic by pathology, and the samples for drug sensitivilty. The clinical stages of the 75 patients according to the TNM classification of malignant tumors by UICC were 29 with stage Ⅳ, 34 with stage, Ⅲ with stage Ⅱ and 2 with stage Ⅰ. The pathological stages of the 75 patients according to three step classification were 18 with stage, 37 with Ⅰ-Ⅱ stage and 20 with Ⅲ stage. The antitumor drugs tested were cisplatin (CDDP) and teniposide (VM-26). Fresh drug was diluted in complete medium at fold of therapeutic peak plasma concentration (Cmax×5) achieved by intr a venous administration of clinical doses. The values were VM026 60μgml-1, CDDP 15μgml-1. The MTT assay was performed in 75 of 81 patients (success rate 92.6%). Results: At a drug concentration of Cmax×5, the inhibition rates of tumors for VM-26 and CDDP were 64.34% and 24.08%, respectively. The inhibition rates of tumor cells for VM-26 were higher than those for CDDP (P<0.01). Conclusion: The inhibition rates of OSCC cells for VM-26 were higher than for CDDP. VM-26 may be as the first selected drug for treating the patients with OSCC.更多还原