【作者】 柳翔云； 周东生； 董宏鹏； 邹德波； 武兴国；

【机构】 山东省立医院骨创伤科；

【摘要】 目的:探讨带血供骨膜包裹胶原基纳米骨(NHAC)修复四肢骨缺损的效果。方法: 使用 NHAC 材料,修复免桡骨干骨缺损,于2、4、6、8、12周后处死各组动物取材,通过大体观测、 X 线、组织形态学观察及计算机图像分析,比较单纯胶原基纳米骨移植、带血供骨膜包裹胶原基纳米骨修复四肢骨缺损的疗效。结果:带血供骨膜包裹 NHAC 在骨缺损修复早期,其成骨速度及成骨质与量均较优越,12周即可使骨缺损完全修复。结论:带血供骨膜包裹 NHAC 对骨缺损的修复能力较强,可大大缩短骨缺损修复时间。更多还原

【Abstract】 Objective:To explore the effect of Nano-Hydroxyapatite/collagen(NHAC)covered by vascularized periost in repairing bone defect in rabbits.Method:NHAC was repaired,a 15mm bone defect experimental model in radius of rabbits were made,the NHAC was implanted into the defects.At 2w,4w,6w,8w,12w after operation,all animals were sacrificed and implant materials with surrounding bone were taken out.To compair the effect of NHAC group and NHAC covered by vascularized periost group by gross,X-ray,histological,scanning electron microscope and analysis of computer merhod.Result:The amount of new bone of early time in NHAC covered by vascularized periost group was much more than another group,and the bone defect was repaired 12w after operation.Conclusion: The repair ability of bone defect in vascularized periost group better than another group,and could de- crease the time of bone defect repairing.更多还原