Ufd1 Is a Cofactor of gp78 and Plays a Key Role in Cholesterol Metabolism by Regulating the Stability of HMG-CoA Reductase

【作者】 曹剑； Russell A.DeBose-Boyd； 宋保亮；

【Author】 Jian Cao Jiang Wang Wei Qi Hong-Hua Miao Jing Wang Liang Ge Russell A.DeBose-Boyd Jing-Jie Tang Bo-Liang Li Bao-Liang Song State Key Laboratory of Molecular Biology,Institute of Biochemistry and Cell Biology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,320 Yue-Yang Road,Shanghai 200031,China

【机构】 State Key Laboratory of Molecular Biology,Institute of Biochemistry and Cell Biology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences；

【摘要】 <正>The membrane-anchored ubiquitin ligase gp78 promotes degradation of misfolded endoplasmic reticulum (ER) proteins and sterol-regulated degradation of HMG-CoA reductase.It was known previously that Ufd 1 plays a critical role in ER- associated degradation (ERAD) together with Np14 and VCP.The VCP-Ufd1-Np14 complex recognizes polyubiquitin chains and transfers the ubiquitinated proteins to the proteasome.Here we show that Ufd1 directly interacts with gp78 and更多还原