【作者】 刘奕； 包扬； 赵震锦； 张扬； 于秉治；

【Author】 Liu Yi, Bao Yang, Zhao Zhenjin, Zhang Yang, Yu BingzhiDepartment of Biochemistry, School of Basic Medical Science, China Medical University, Shenyang 110001, China, E-mail: ybzbiochem@yeah.net

【机构】 中国医科大学基础医学院生物化学教研室；

【摘要】 目的:研究mTOR/P70 S6K激酶信号通路激活在腮腺腺癌中的作用。方法:用免疫组化方法及Western印迹分析测定腮腺腺癌中mTOR和P70 S6的表达。结果:免疫组化与Westem印迹分析的结果一致:和正常组织相比,腮腺腺癌中mTOR和P70 S6K的表达明显增加。结论:口腔腮腺腺癌mTOR和P70 S6K的表达增加可能是介导腮腺腺癌发生的主要机制之一。更多还原

【Abstract】 Objective: The aim of this study is to observe the expression of mTOR(mammalian target of rapamycin) and P70 S6 kinase(P70 S6K) signal pathway in oral parotid adenocarcinoma. Methods: mTOR and P70 S6 kinase were examined by means of SP immunohistochemical technique and Western-blot test. Results: The expression level of mTOR and P70 S6K increase obviously in oral parotid adenocarcinoma tissue. The expression of Immunological assay is same as the Western-blot. Conclusions: Higher expression of mTOR and P70 S6K may involve in the pathogenesis of oral parotid adenocarcinoma.更多还原