【作者】 吕雪莹； 张凤蕴； 王丽群； 于伟玲； 张莉；

【Author】 LU Xue-ying, ZHANG Feng-yun, WANG Li-qun, et al (Department of Immunology; Department of Electron Microscope, Harbin Medical University, Harbin 150086, China)

【机构】 哈尔滨医科大学免疫教研室； 哈尔滨医科大学电镜室；

【摘要】 目的研究实验性变态反应性脑脊髓炎(EAE)的病理变化。方法利用光镜、电镜观察豚鼠EAE模型的组织学改变。结果光镜下可见脑实质及珠网膜下腔小血管,血管周围炎细胞浸润,呈“袖套”状改变,侧脑室旁白质及脊髓后联合、侧角出现髓鞘肿胀、崩解或消失。电镜下可见血管周围明显脱髓鞘,髓鞘呈松散状,部分区域斑块状脱落,明暗相间结构消失,轴突变细胞器消失,神经元细胞尼(氏)小体消失,内质网扩张脱颗粒。结论 EAE 的病理改变主要为血管周围炎性浸润及白质脱髓鞘。更多还原

【Abstract】 Objective To investigate pathological characteristics of EAE model. Methods The pathological changes of EAE were studied in guinea pig with the aid of light and electron microscope. Results the characteristic light microscopical findings are summarized in the following; congestion and inflammatory cuffs of small blood vessels were evident within cerebral parenchyma and subarachnoid cavity. Swelling, disintegration and disapear of myelin shealth were observed both in white matter of lateral ventricle and in lateral bom as well as posterior commissure of spinal cord. Electron microscopy showed evident demyelination around blood vessels. Nissle bodies in neurons were disappeared. Conclusion EAE is characterised by perivascular inflammatory cell infiltration and demyelination in white matter.更多还原