【作者】 张凤蕴； 宋英娜； 王丽群； 于伟玲； 张丽君；

【Author】 ZHANG Feng-yun, et al (Dept. of Immunology of Harbin Medical University 150086)

【机构】 哈尔滨医科大学免疫学教研室； 山东省龙口市中医院；

【摘要】 应用双抗体夹心检测22例溃疡性结肠炎(UC)患者血清中可溶性白细胞介素-2受体(sIL-2R)水平,用 PEG-紫外分光法测定循环免疫复合物(CIC)水平,用红细胞C3b受体花环试验及免疫复合物花环试验检测红细胞免疫粘附功能。结果显示:UC患者血清中sIL-2R、CIC水平均明显高于正常人(P<0．001,P<0．001),红细胞C3b 受体花环率明显低于正常人(P<0．001),红细胞免疫复合物花环率则较正常人明显升高(P<0．001)。表明UC患者细胞及体液免疫功能紊乱,红细胞免疫功能低下。这几项免疫功能指标的检测,对UC的辅助诊断、病情观察及预后评估具有一定参考意义。更多还原

【Abstract】 In 22 patients with ulcerative colitis (UC), the double antibody sandwich method was used to determine the soluble interleukin-2 receptor(sIL-2R) levels, the PEG-ultraviolet spectrophotometer was used to determine the circulating immune complex(CIC) levels,and the RBC C3b receptor rosette test (RC3bRRT) and the RBC immune complex receptor test (RICRT) were used to determine the RBC immune adhesive capacity. The results showed that the sIL-2R and the CIC levels were much higher in the patients with UC than in the healthy people( P < 0.001), the RC3bRR rate was much lower( P < 0.001), and the RICR rate was much higher(P <0.00l) .which suggested that Cellular and humoral immunofunction of patients with UC were disturbed and the RBC immunity function was lowered. The determination of these indexes could be helpful in making an accessory diagnosis, monitoring progression of the disease and evaluating the prognosis.更多还原