【作者】 宾晓农； 谭敏； 丁愈； 曾晓莉； 林立白； 凌艺辉； 吕嘉春； 陈家堃；

【Author】 BIN Xiao-nong,et al. Institute for Chemical Carcinogenesis,Guangzhou Medical College,Guangzhou 51018

【机构】 广州医学院化学致癌研究所； 广州中医药大学第二附属医院病理科； 湖南省株洲市疾病预防控制中心； 湖南省株洲市职业病防治所；

【摘要】 [目的]研究冶炼工人体内镍(Ni)、铬(Cr)负荷与自由基代谢变化的关系。[方法]以212名冶炼作业人员为接触组,以106名无镍、铬接触史的健康人作为非接触组,分别测定两组人员血清中Ni、Cr的含量作为体内负荷,同时测定两组人员血清中丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)和谷胱甘肽硫转移酶(GST)水平,并将上述各项指标进行相关分析。[结果]接触组血清Ni、Cr平均水平分别为0.15±0.04和0.26±0.03μmol/L,血清SOD、GSH-Px和GST的活性分别为161.22±29.26、116.42±20.16和38.36±10.06U,MDA含量为7.32±2.35μmol/L;非接触组血清Ni、Cr平均水平分别为0.07±0.05和0.08±0.04μmol/L,血清中SOD、GSH-Px和GST的活性为181.61±28.34、153.14±20.36和46.20±10.26U, MDA含量为4.35±1.26μmol/L。接触组与非接触组上述对应各项指标进行统计学分析,差异呈高度显著性(p<0.01)。将接触组人员以工龄分组比较,显示≥10年工龄组比较短工龄组(≤5年)血清Ni、Cr平均水平和MDA含量均较高(P<0.05);SOD、GSH-Px和GST活性较低(P<0.05)。[结论]镍、铬具有增加体内脂质过氧化产物含量,降低机体的抗氧化能力,可能为增高镍、铬接触人群氧化应激易感性。更多还原

【Abstract】 [Objective]In order to study relationship between Ni、Cr exposure and lipid peroxidation metabolism on occupational population.[Method]212 metal workers occupationally exposed to Ni and Cr were selected the exposure group,and 106 workers without any exposure to Ni and Cr as the control group.Two groups were statistically similar about sex,age and smoking habit. Quantities ofNi,Cr and MDA,and activities of SOD,GSH-Px and GST in serum were determined in two groups.[Results]The levels of MDA,Ni and Cr of the exposure group were significantly higher[7.32±2.35,0.15±0.04 and 0.26±0.03μmol/L]than those of the control group[4.35±1.26, 0.07±0.05 and 0.08±0.04μmol/L],P<0.05.The activities of SOD,GSH-Px and GST of the exposure group were significantly lower[161.22±29.26、116.42±20.16 and 38.36±10.06U]than those of the control group[181.61±28.34、153.14±20.36 and 46.20±10.26U],P<0.05.In addition,when stratified by length of service,statistical difference could be found.[Conclusion]Ni and Cr can induce the lipid peroxidation in metal workers occupationally and decrease the ability of antioxidant.更多还原