【作者】 袁飞； 胡绍源； 陆朝国； 路永强； 王国俊； 白敏；

【Author】 YUANFei~1,HU Shaoyuan~1,LU Chaoguo~1,LU Yongqiang~2,WANG Guojun~3,BAI Min~1. (1、The Guiyang Center for Disease Prevention and Control,Guizhou Guiyang 550003,China;2、The Huaxi District Center for Disease Prevention and Control,Guizhou Guiyang 550011,China;3、Infirmary of Gaopo Village Huaxi District,,Guizhou Guiyang 550011,China)

【机构】 贵阳市疾病预防控制中心； 花溪区疾病预防控制中心； 花溪区高坡乡卫生院；

【摘要】 目的探索一起以多神经炎症状为主的不明原因疾病暴发流行的病因,预防控制类似疾病的发生与流行。方法采用流行病学现况调查及实验室检测进行了连续5年的调研。结果该"不明原因疾病"的发病率为8.51%;从病人粪便标本中分离出1株柯萨奇B组2型病毒,并与其双份血清中和抗体反应呈两倍变化,另有5例病人血清中和抗体滴度大于1:160或1:320;病区煤、土壤、大米、辣椒及病人发砷含量均超过国家标准;病人血红蛋白(Hb)及维生素B1(VitB1)值在正常范围。通过抗病毒治疗病人基本痊愈。结论病因调查结果认为,此次多神经炎暴发流行不排除病毒感染,不排除环境介质中砷含量较高。更多还原

【Abstract】 Objective There broke out an uncertain disease,with some symptoms similar to that of neuritis.Investigation wasperformed to explore its cause so as to prevent similar diseases from taking place again.Methods We studied it with epidemics method and experiments fiom 1995 to 1999.Results Incidence of the disease was 8.51%.The CoxB2 virus was separated from faeces of patients,and there was a two-fold changes of the reaction of serum neutralizing antibody in acute period and recuperative period.In addition,the titer of serum neutralizing antibody in five patients was over 1:160 or 1:320;The arsenic contents in the coal,soil,paddy,cayenne in the area and the patient hair were above the standard.Patient’s hemoglobin and Vitamin B1 contents were normal.The patients were cured through systematic antiviral treatment. Conclusion The disease is related to the infection by virus,but higher arsenic contents in environment could not be ruled out as one of the causes.更多还原