【作者】 曹建平； 王文祥； 廖惠珍； 林崴； 杨金德；

【Author】 CAO Jian-ping,WANG Wen-xiang,LIAO Hui-zhen,et al.Department of Nutrition and Health Care,Institute of Public Health,Fujian Medical University.(Fuzhou 350004,China)

【机构】 福建医科大学公共卫生学院社区卫生与全科医学系； 福建医科大学公共卫生学院营养与保健医学系； 福建医科大学公共卫生学院；

【摘要】 目的观察亚慢性镉暴露对雄性大鼠生殖系统及生育功能的影响。方法24只清洁级SD雄性大鼠按体重大小随机分为四组:（1）对照组、（2）低剂量染镉组、（3）中剂量染镉组、（4）高剂量染镉组。其中（2）-（4）组分别予皮下注射0.1、0.2、0.4mg Cd²⁺/kg.体重,对照组给予皮下注射等量生理盐水,隔日染毒1次,每周3次,连续染毒4周。染毒结束后雄、雌性大鼠按1:1合笼交配一周。雄性大鼠交配结束后处死,解剖取睾丸、附睾等待检,雌性大鼠则于交配成功后第10天处死,检查是否受孕成功。结果高剂量染镉组体重增长值明显低于对照组（p<0.05）;低、中、高剂量染镉组大鼠的精子计数和精子活动率均低于对照组（p<0.05）;而畸形率明显高于对照组（p<0.05）,且有明显的剂量—反应关系。交配率和受孕率随着染毒剂量的加大而下降（p<0.05）。结论亚慢性镉暴露可明显降低雄性大鼠的精子质量,进而影响生育功能。更多还原

【Abstract】 Objective To study the toxicity effects of cadmium on the male reproductive systems and ability.Methods 24 male rats were randomly divided into 4 groups respectively.Different groups were injected sc with a dose of 0、0.1、0.2、0.4mg Cd²⁺/kg body weight,once a day,three times per week for 4 weeks.After cadmium exposure,the male rats were watched with normal female rats at the ratio of 1:1 for one week.Then the male rats were sacrificed and the testis,epididymises were separated to examine.While the female rats were sacrificed and the number of fetuses were measured on the 10th day of the pregnancy. Results The increase of body weight in the high dose group were significantly lower than those in the control group（p<0.05）.The sperm concentration and viability rate in each cadmium exposure group were obviously lower than those in the control（p<0.05）.The malformation rate in the low、middle、high group were obviously higher than control group（p<0.05）.A dose-response relationship between the dose of cadmium and the sperm concentration and malformation rate was found.Conclusion The exposure of cadmium can significantly decrease the reproductive ability.更多还原