【作者】 牛萍； 王芳； 王晋明； 胡晓军； 王蕊；

【Author】 Niu Ping, Wang Fang, Wang Jinming,et al Departament of Cardiology, Renmin Hospital of Wuhan University,Wuhan, 430060

【机构】 武汉大学人民医院心内科；

【摘要】 目的:探讨湖北地区汉族人群肾上腺髓质素基因(ADM)微卫星多态性(CA重复序列) 的分布特点。方法:应用聚合酶链反应技术(PCR),检测196例正常人的ADM基因的微卫星多态性,同时结合文献,比较不同种族间等位基因频率总体分布的特点。结果:ADM基因型总体分布在男女间无显著性差异(X2=5．92,P>0．05),在4种等位基因频率中,11、13及14占优势,19值稀少,其总体分布也无显著性差异(X2=0．314,P>0．05)。中国汉族正常人群与日本普通人群ADM 基因等位基因频率分布无显著性差异(X2=0．178,P=0．981)。结论:ADM基因多态性在中国汉族正常人群中的分布与性别无关,与日本普通人群中的分布相近。更多还原

【Abstract】 Objective: To identify the microsatellite DNA polymorphism of adrenomedullin (ADM) gene in healthy normotensive subjects, and analyze the characterizaton of gene distribution among different races. Method: :With polymerase chian reactiona(PCR), ADM genotyping was performed in 196 normotensive subjects in Hubei area. Results: The genotype distribution and allele frequency of ADM between male and female groups was not significantly different. Compared with Japanese population, allele frequency was not significantly different. Conclusion: Microsatellite DNA polymorphism of adrenomedullin gene may be independent on gender, and like in Japanese population.更多还原