【作者】 高方友； 杨辉； 张治元；

【Author】 GAO Fang-You, YANG Hui,ZHANG Zhi-Yuan (Department of Neurosurgery,Xinqiao Hospital,Third Military Medical University, Chongqing 400037)

【机构】 贵阳医学院附属医院神经外科； 第三军医大学附属新桥医院神经外科；

【摘要】 中枢神经移植治疗帕金森病未能得到广泛开展的主要原因是伦理道德问题和不能获取足量的供体组织等。因此,尝试基因工程化干细胞使之成为多巴胺能神经元以释放多巴胺递质来达到治疗的目的是目前研究的热点。核受体相关因子-1 (nuclear receptor related factor 1,Nurr1)基因与多巴胺能表型产生有密切的关系,本文对Nurr1基因使干细胞向多巴胺能表型神经元样细胞分化的研究进展进行了综述,并提出了今后的研究方向。更多还原

【Abstract】 Neural transplantation for the treatment of Parkinson’ s disease(PD) has been restricted by some issues, for example source of donor cells, ethics, etc. In vitro expanded stem cells could provide a renewable source of dopaminergic neurons for cell therapy and without ethical restriction. Maybe, it is a useful strategy that gene engineering generated dopaminergic neuron to replace lost neurons in PD. Here we will discuss the relevance for Nurrl gene, an orphan nuclear receptor and dopaminergic phenotype in mesencephalon and olfactory bulb, and review the recent advances in Nurrl gene differentiating stem cells into dopaminergic neuron.更多还原