【作者】 游秀东； 高建平； 朱孟府； 张西正；

【Author】 YOU Xiu-dong~1 GAO Jian-ping~2 ZHU Meng-fu~1 ZHANG Xi-zheng~1 (1.Instite of Medical Equipment,Acdemy of Military Medical Sciences,Tianjin 300161,China; 2.School of Science,Tianjin University,Tianjin 300072,China)

【机构】 军事医学科学院卫生装备研究所； 天津大学理学院；

【摘要】 对硫酸庆大霉素/α半水硫酸钙载药体系进行了模拟条件下体外释药研究,并对其晶体结构进行了分析．X-射线衍射分析结果表明,载药体系中一定含量的硫酸庆大霉素不会影响α半水硫酸钙的水化；模拟条件下体外释药研究表明,各种药物含量的载药体系均表现出了良好的缓释性能,持续释放时间超过了360h；随着试样中载药量的增加,其药物释放速率加快；另外, 构制了均一分散和核壳结构两种载药体系,研究结果表明,均一分散型在前期释放速度要大于核壳结构型,而后期核壳结构型则比均一分散型要高．更多还原

【Abstract】 In this study,we have prepared α-calcium sulfate hemihydrate-gentamicin tablets,and determined the in vitro elution characteristics of gentamicin from them.Results from X-ray diffraction study indicates that the quantificational gentamicin did not prevent the hydration of α-calcium sulphate hemihydrate.In vitro drug release study showed that when gentamicin incorporated in to calcium sulfate hemihydrate tablets,they can prolonged release from the carrier tablets,it release could sustain over 360 hours.And the best structure is core/shell structure which can slower the drug release rate. The drug release rate increased with the quantity of gentamicin increasing.更多还原