【作者】 赵东林； 赵洪叶； 夏启胜； 唐劲天；

【Author】 ZHAO Dong-lin, ZHAO Hong-ye, XIA Qi-sheng, TANG Jin-tian (State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029,China; Institute of Carbon Fiber and Composites, Beijing University of Chemical Technology, Beijing 100029, China; Institute of Clinical Medical Sciences, China Japan Friendship Hospital, Beijing 100029,China; School of Medicine, Tsinghua University, Beijing 100084, China)

【机构】 北京化工大学化工资源有效利用国家重点实验室； 中日友好医院临床医学研究所； 清华大学医学院；

【摘要】 用水解沉淀法合成了纳米Fe3O4粒子,研究了纳米Fe3O4粒子在交变磁场下的发热性能,对它在定向集热治疗肿瘤中的应用前景进行了评价。纳米 Fe3O4粒子的粒径为10-30nm,纳米Fe3O4粒子的比饱和磁化强度为48．06Am2／kg,矫顽力为10．1kA／m。随着纳米Fe3O4粒子浓度的增加生理盐水悬浮液在交变磁场中的升温速率逐渐增加,纳米Fe3O4粒子含量大于50mg／ml时,在外加交变磁场作用下12min后, 纳米Fe3O4粒子悬浮液的温度大于45℃,达到了医学上定向集热治疗肿瘤用热籽的发热要求,纳米Fe3O4 粒子是很有应用前景的医用纳米材料。更多还原

【Abstract】 The Fe3O4 nanoparticles with diameter of 10-30nm were prepared by coprecipitation. The inductive heating property of Fe3O4 nanoparticles in an alternating current magnetic field was investigated. The potential of the Fe3O4 nanoparticles was evaluated for localized hyperthermia treatment of cancers. The saturation magnetization Ms and coercivity Hc of Fe3O4 nanoparticles are 48. 06Am2 /kg and 10. 1kA/m respectively. The temperatures of physiological salt water suspension containing Fe3O4 nanoparticles increased with the increase of the concentration. Exposed in the alternating current magnetic field for 12min, the temperatures of physiological salt water suspension containing Fe3O4 nanoparticles with concentration of more than 50mg/ml are higher than 45℃. The Fe3O4 nanoparticles would be useful as good thermoseeds for localized hyperthermia treatment of cancers.更多还原