【作者】 刘文斌； 姜崇喜； 沈如； 冯波； 屈树新；

【Author】 LIU Wen-bin, JIANG Chong-xi, SHEN Ru, FENG Bo, QU Shu-xinKey Lab. of Advanced Technologies of Materials, Ministry of Education, School of Material Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China

【机构】 西南交通大学材料科学与工程学院材料先进技术教育部重点实验室；

【摘要】 以Ca(NO3)2、(NH4)2HPO4和明胶为起始原料,采用原位合成的方法,制备与自然骨成分和结构相似的羟基磷灰石/明胶复合材料(HA/Gel).采用各种分析手段对样品进行表征.红外结果表明HA/Gel中波数为1339cm-1的酰胺基团向低波数发生了红移;X射线衍射证明HA/Gel复合材料中的无机相主要为低结晶度、晶粒尺寸细小的羟基磷灰石;热重结果证明本试验制备的HA/Gel中Gel的含量达到15%左右;采用扫描电镜现察HA/Gel复合材料的微观形貌.扫描电镜观察发现HA颗粒定向分布在Gel连续相基体上,本试验结果证明HA与Gel形成键性结合,是一种颇有前途的骨组织替换材料.更多还原

【Abstract】 The aim of the present study was synthesized hydroxyapatite/gelatin (HA/Gel) composite, of which the composition and structure was similar to that of natural bone. Analyzed grade Ca(NO3)2, (NH4)HPC4 and gelatin were used as the staring materials to synthesized HA/Gel composite in situ. Scanning Electronic Microscopy(SEM), Fourier transform infrared (FTJR), X Ray Diffraction (XRD) and Thermal Analysis (TA) were used to characterize HA/Gel composite. SEM observed that HA/Gel was sponge whereas HA was more dense.Ft-IR results showed that the adsorption peaks of amide Ⅰ, Ⅱ and Ⅲ were present besides the adsorption peaks of OH and PO4. XRD results showed that the main crystal phase was HA, which possessed the poorer crystallinity, smaller grain size. TA results demonstrated that there were about 9.2% Gel in the HA/Gel composite. DTA curves confirmed that the obvious exothermic peak was present from 300-550℃, which indicated the decomposition of Gel. The present results showed that the chemical bond might be formed between gelatin and hydroxyapatite. It was concluded that the newly developed composite was a hopeful bone replaced material.更多还原