【作者】 许东晖； 王胜； 梅雪婷； 许实波；

【Author】 XU Dong-hui WANG Sheng MEI Xue-ting XU Shi-bo Lab.of Traditional Chinese Medicine and Marine Drugs,School of Life Sciences,Sun Yat-sen University,Guangzhou 510275,Guangdong,China

【机构】 中山大学生命科学学院中药与海洋药物研究室；

【摘要】 目的利用聚乙烯吡咯烷酮K30(PVP K30)制备姜黄素固体分散体开展对实验性胃溃疡的药理研究。方法选择PVPK30作为载体,用溶剂法制备姜黄素固体分散体,建立大鼠醋酸致胃溃疡、幽门结扎性胃溃疡以及小鼠利血平诱导胃渍疡等模型观察姜黄素固体分散体抗胃溃疡作用。结果与纯姜黄素相比,姜黄素固体分散体(姜黄素:PVP的质量比为1:8)溶解度提高了880倍以上,溶出速度明显增大。确定姜黄素固体分散体中姜黄素与PVP的最佳质量比为1:8。幽门结扎致胃溃疡、乙酸烧灼致胃溃疡、利血平诱导胃溃疡模型实验表明:与模型组相比,口服给予姜黄素固体分散体能够明显降低动物的溃疡指数,对胃液含量、胃酸分泌及胃蛋白酶活性均具有显著的抑制作用,同时显著提高大鼠的血清NO水平升高,降低血浆ET水平。结论姜黄素固体分散体应用在治疗胃溃疡具有很好的开发前景。更多还原

【Abstract】 OBJECTIVE Studies on anti-gastric ulcer effect ofcurcumin solid dispersion by polyvinylpyrrolidione K30(PVP K30).METHODS Curcumin-PVP K30 solid dispersions(SDs)were prepared by co-evaporation in ethanol solution.The gastroprotective effects of oral administration Curcumin-PVP K30 SDs were studied by gastric ulcer rat models induced by acetic acid,ligated pylorus,and reserpine.RESULTS The results showed that curcumin-PVP K30 SDs couM reduce the ulcer indexes and plasma ET level,and increasing the serum NO level,decrease the volume and acidity of gastric juice,and the activity of pepsin.CONCLUSION The solid dispersion in PVP k30 improves the solubility of curcumin.These findings show a potential application of curcumin SDs as a anti-ulcerogenic drug.更多还原