【作者】 周扬； 顾杰； 徐列明；

【机构】 上海中医药大学肝病研究所；

【摘要】 目的研究丹参酚酸 B（SA-B）盐对内皮素-1（ET-1）致大鼠门静脉压力升高效应的作用。方法 28只大鼠随机分为 SA-B 组、ET_AR 阻断剂（BQ-123）组、ET_BR 阻断剂（BQ-788）组和对照组, SA-B 组大鼠给予 SA-B 溶液灌胃、其余3组给予饮用水灌胃,共5d;ET_AR 阻断剂和 ET_BR 阻断剂两组于实验前30min 从大鼠股静脉分别注入 BQ-123和 BQ-788,然后各组大鼠经股静脉以3μg·kg^-1剂量注射 ET-1溶液,观察大鼠门静脉压力、颈动脉压力和心率的变化。结果注 ET-1后大鼠门静脉压力升高,以对照组升高幅度最大,预先灌服 SA-B 溶液或提前注入了 ETR 阻断剂的大鼠门静脉压力虽然也升高,但升高幅度较对照组显著降低。结论 SA-B 在体内能够明显抑制 ET-1所致的门静脉压力升高,有类似 ETR 阻断剂的作用。更多还原

【Abstract】 Objective To investigate the effects of Salvianolic-acid B on portal hypertension induced by endothelin-1 in rat.Methods 28 Sprague-Dawley rats were randomly divided into four groups:SA-B group,ETAR blocker (BQ-123) group,ET_BR blocker (BQ-788) group and control group.The rats of SA-B group underwent intragastrical administration of Salvianolic-acid B for five days proceeding ET-1 injection,while in three other groups drinking water was given.In BQ-123 group or BQ-788 group,an intraveneous injection of BQ-123 or BQ-788 via femoral vein was administrated one hour prior to ET-1 injection.Then changes of portal pressure,cervical artery pressure and heart rate were monitored continuously.Results After ET-1 injection,the portal pressure of all rats in control group increased significantly,while slightly in groups that pretreated with SA-B,BQ-123 or BQ-788.Conclusion SA-B can attenuate elevated portal pressureinduced by ET-1 with effect similar to ETR blocker.更多还原