【作者】 张红新； 赵阿红； 宋一民； 高冬玲； 张岚； 张云汉；

【Author】 ZHANG Hongxin, ZHAO Ahong, SONG Yimin, GAO Dongling, ZHANG Lan, ZHANG Yunhan (Department of Pathology of the First Affiliated Hospital, Zheogzhou University; Henan Key Laboratory of Tumor Pathology, Zhengzhou 450052, China)

【机构】 郑州大学第一附属医院病理科河南省肿瘤病理重点实验室；

【摘要】 目的探讨人食管鳞癌组织中的淋巴管生成及其与淋巴结转移的临床意义。方法采用酶组织化学法,检测 49例食管鳞癌、癌旁及切端正常食管上皮组织中淋巴管的生成及定位特征,并应用图像分析方法测定淋巴管数量和阳性单位、及其与淋巴结癌转移的关系。结果肿瘤组织中淋巴管生成和阳性单位均与淋巴结转移密切相关(P<0．01), 癌旁组织中淋巴管密度高于癌组织(P<0．01),酶组织化学法可较好地显示食管鳞癌组织中的淋巴管。结论食管鳞癌的淋巴管形成与淋巴结转移相关,为肿瘤细胞琳巴道转移提供了条件。更多还原

【Abstract】 Objective To study the relationship between lymphangiogene-sis in human esophageal squarooua cell carcinoma ( ESCC) and the lymph node metastasis of ESSC. Method Numbers of lymphatic vessel density (LVD) and its positive unit ( PU) in ESCC tissues from 49 cases were detected by the enzyme-histochemical method and the image analysis system. The relationship was verified between LVD and PU by enzyme-histo-chemistry and the lymph node metastasis of ESSC. Results There was a statistically positive correlation between lymphangiogenesis, PU and lymph node metastasis in ESSC (P <0. 01). LVDs of at the tumor periphery were significantly higher than that of in investigated tumor area ( P < 0.01). The enzyme-histochemical method showed clearly intratumorous lymphatic vessels of ESCC. Conclusion There is a close relationship between lymphangiogenesis and lymph node metastatic tumors in ESCC. Lymphangiogenesis might play a role in lymphatic metastasis.更多还原