【作者】 陈惟昌； 陈志华； 潘琳； 赵天德； 周东辉； 王自强； 唐劲天； 黎刚； 朱佩平； 姜晓明； 吴自玉；

【Author】 CHEN Weichang CHEN Zhihua PAN Lin ZHAO Tiande ZHOU Donghui WANG Ziqiang TANG Jintian (China Japan Friendship Institute of Medical Sciences,Beijing 100029)LI Gang ZHU Peiping JIANG Xiaoming WU Ziyu (Institute of High Energy Physics,Chinese Academy,Beijing 100039)

【机构】 中日友好临床医学研究所； 中国科学院高能物理研究所；

【摘要】 当前医学影像学的发展趋势是提高人体软组织成像的衬度分辨率及空间分辨率,由宏观影像学向微观影像学的方向发展。微观影像学能看见微米级的组织和细胞结构,能在活体上无损和动态地观察人体内部器官的微细病理变化,从而能早期作出准确的细胞病理学的定性和定位诊断,以及早期进行精确的定点清除治疗。在提高软组织成像的衬度分辨率方面,相位衬度成像技术是国内外关注的热点。据报道,软组织的X 射线相位衬度的分辨率约为常规X 射线CT 吸收衬度分辨率的1000倍。本文以北京同步辐射装置产生的同步X 射线束为光源,应用衍射增强成像(DEI)技术,对人和动物脏器的软组织进行相位衬度成像。结果表明:相位衬度显微成像可清晰显示肺泡、肾小管、肝小叶等微细的组织结构,这些在常规X 射线CT 吸收衬度成像是看不见的。医学相位村度显微CT 成像将是医学显微影像学的未来发展方向。更多还原

【Abstract】 Recent development of the medical imaging is the changing from macroimaging to themicroimaging by improving the spatial resolution and the contrast resolution of the soft tissues.Cells andmicrostructure of um magnitute can be visualized in vivo noninvasivily and dynamically by medicalmicroimaging technique.Medical microimaging is capable of making the pathological diagnosis moreearly and the treatment of the leision more precisely by γ knife.Because the phase contrast resolution of Xray in soft tissues is about one thousand times higher than that of the absorption X ray method,so thephase contrast imaging is becoming the hot spot of the medical imaging.In this paper,the synchrotron Xray source at BSRF was used to investigate the microstructure of lung,liver and kidney by means of theDEI phase contrast microimaging method.Results indicated that the microstructures of lung alveoli,renaltubulus,liver lobules etc,which could not be seen by conventional absorption X ray method but could berevealed clearly by phase contrast imaging method.It is concluded that the medical phase contrastmicro-CT is a new developing technique of the medical imaging in the near future.更多还原