【作者】 张俊刚； 徐颖； 陈淑芬； 杨卫超； 姜红； 郭金铭；

【Author】 Zhang Jungang Xu Ying Chen Shufen Yang Weichao Jiang Hong Guo Jinming (Hebei Provincial Center for Disease Prevention and Control,Shijiazhuang050021)

【机构】 河北省疾病预防控制中心；

【摘要】 研究葡萄籽提取物复合物的抗氧化作用。将昆明小鼠随机分组,高、中、低剂量组分别经口给予不同浓(0.44g·kg^-1、0.87g·kg^-1、1.31g·kg^-1)受试样品, 空白对照组则给予同体积溶剂（去离子水）,连续给样品30后取血测抗氧化酶活力,次日给受试样品或溶剂1h 后,用溴代苯油(0.47g·kg^-1)造模致肝损伤,测定肝组织抗氧化酶活力和过氧化脂质含量。复合物高剂量组血清总超氧化物歧化酶 （SOD）活力显著高于空白对照组（p<0.01）,复合物高剂量组血清谷胱甘肽过氧化物酶（GSH-Px）活力显著高于空白对照组（p<0.01）。中、高剂量组肝组织过氧化脂质丙二醛（MDA）的含量显著低于模型对照组（p<0.01）。结果显示该复合物具有一定的抗氧化能力,对肝组织脂质过氧化损伤具有一定保护作用。更多还原

【Abstract】 This paper studied the protective effect of a kind of complex on anti-oxidation.72 mice were randomly divided into 6 groups,which included blank control group,model control group,solvent group and three drug orally administrated groups(0.44g·kg^-1、0.87gg·kg^-1、1.31g·kg^-1). The activity of anti-oxidation enzyme in blood was tested for three doses of groups and blank control group after 45 days of consecutive drug or solvent giving.Experimental liver injury was induced by bormobenzene (0.47g·kg^-1)in drug groups and model control group on the 46th day. Content of MDA and GSH-Px and SOD in liver homogenate were determined. Compared with blank control group,the high dosage group showed a significantly higher activity of SOD and GSH-Px activity（p<0.01）.While compared with the model group,the MDA content in middle and high dose groups were significantly lower（p<0.01）.The results suggested this kind of complex’s some anti-oxidation function and protective effects from lipid peroxide injury in liver.更多还原