糖胃康对糖尿病胃轻瘫大鼠胃肽能神经的影响

【作者】 肖万泽； 付伟； 陈俊； 张萌； 毕会民；

【机构】 湖北省中医院内分泌科； 武汉大学人民医院内分泌科；

【摘要】 目的:探讨中药复方糖胃康对糖尿病胃轻瘫(简写DGP)大鼠胃肽能神经的影响。方法:将实验大鼠分为正常对照组、模型对照组、糖胃康大、小剂量组、胃复安组,分别给药灌胃4周后处死,取胃窦部组织测定并分析其肽能神经面积和光密度。结果:模型组与空白对照组大鼠比较,VIP、CGRP神经面积、光密度均有显著降低(P<0.01),糖胃康大、小剂量组与模型组比较,VIP、CGRP神经面积、光密度均有明显上升(P<0.01或P<0.05),而胃复安组VIP、CGRP神经面积、光密度则无明显变化(P>0.05)。结论:中药糖胃康可显著以改善DGP大鼠的胃肽能神经病变。更多还原

【Abstract】 Aim:To probe into the impact of a patent herbal medicine—TangWeiKang on the gastric peptidergic nerves of rats with diabetic gastroparesis(DGP).Methods:Experimental rats were divided into five groups,namely,normal control group,model control group,large- dose TangWeiKang group,small- dose TangWeiKang group and Metoclopramide group.The rats were drip-fed with relevant drugs for four weeks running and then they were killed and tissue from gastric antrum of each rat was taken to measure and analyze the optical density and area of VIP as well as CGRP.Results:The optical density and area of both VIP and CGRP of model group were dramatically lower than those of blank control group(p < 0.01).After four- week treatment with TangWeiKang,the optical density and area of VIP and CGRP of large- dose or small- dose TangWeiKang group were both evidently higher in comparison with those of model group(p < 0.01 or p < 0.05) while the outcome of Metoclopramide group remained the same in effect(p > 0.05).Conclusions:The traditional Chinese medicine—TangWeiKang can improve neuropathological changes of DGP- afflicted rats.更多还原