【作者】 李惠林； 张志玲； 朱章志； 熊曼琪； 黄从强；

【Author】 LI Hui-lin,ZHANG Zhi-ling,ZHU Zhang-zhi,XIONG Man-qi,HUANG Cong-qiang.SHENZHEN HOSPITAL OF TRODIONAL MEDICINE, 518033

【机构】 深圳市中医院； 广州中医药大学第一临床医学院糖尿病研究所；

【摘要】 <正>现代生物医学研究表明,氧自由基(Oxygen Free Radicals,OFR)对胰岛β细胞的毒性作用及其对血管及神经的过氧化损伤是引起糖尿病及其并发症的主要因素之一。目前国内尚未见治疗糖尿病中药对氧自由基的影响的相关报道。本文采用腹腔注射链脲佐菌素(STZ)诱发糖尿病的方法造成实验性糖尿病大鼠模型,研究其血浆过氧化脂质水平和红细胞超氧化物歧化酶活性的变化,观察了中药活血降糖饮对大鼠模型氧自由基的干预作用,现报告如下。更多还原

【Abstract】 Object:To observe the effect HUOXUEJIANGTANGYIN(活血降糖饮) had on oxygen free radicals of experimental diabetic rats.Methods:56 streptozotocin(STZ)-induced diabetic rats were devided to 4 groups and 15 normal rats were devided to normal control group.After treatment,blood glucose,blood lipids,lactoperoxidase(LPO) and superoxide dismutase(SOD) were detected. Results:Level of LPO of diabetic rats significantly increased and activity of SOD of diabetic rats significantly decreased(p<0.01).After treatment,level of LPO of diabetic rats decreased somewhat,activity of SOD gradually recovered in diabetic rats of treated groups,were significantly different from blank control group(p<0.01),but there were no significant differences among each of treated group(p>0.05).Conclution: HUOXUEJIANGTANGYIN(活血降糖饮) can resist OFR of experimental Diabetic rats to some extent.更多还原