【作者】 霍海如； 谭余庆； 李晓芹； 郭淑英； 周爱香； 田甲丽； 孙玉茹； 贺玉琢； 姜廷良；

【Author】 Huo Hairu,Tan Yuqing,Li Xiaoqin,Guo Shuying,Zhou Aixiang, Tian Jiali,Sun Yuru,He Yuzhou,Jiang Tingliang (Institute of Chinese Materia Medica,China Academy of TCM,Beijing,100700)

【机构】 Institute of Chinese Materia Medica,China Academy of TCM；

【摘要】 在酵母诱导的发热大鼠中,桂枝汤有效部位A(Fr.A)能降低隔区AVP和下丘脑NT含量,对下丘脑AVP含量无影响;在安痛定诱导的低体温大鼠中,Fr.A能提升下丘脑、隔区AVP含量和下丘脑NT含量。结果提示,Fr.A对发热动物的解热作用与影响下丘脑NT和隔区AVP的释放有关;抑制中枢AVP和NT的释放或利用参予Fr.A对低体温的调节过程。更多还原

【Abstract】 Active fraction A(Fr.A),isolated from Guizhi decoction,might lower febrifacient temperature induced by yeast in febrile rat with decreasing contents of arginine vasopressin (AVP) in ventral septal area(VSA) and neurotensin(NT) in hypothalamus.Fr. A did not influence the content of AVP in hypothalamus.In aminopyrine-induced hypothermal rats,Fr.A could raise body temperature and contents of AVP in both hypothalamus and VSA and NT in hypothalamus.The results indicated that febrifugal effect of Fr.A was related with its promoting release of AVP in VSA and NT in hypothalamus, while its inhibiting release and/or action of AVP and NT in the thermoregulatory center was involved in mechanism of Fr.A ragulating hypothermia.更多还原