【作者】 卿晨； 张金生； 丁健；

【Author】 QING Chen Zhang jin-sheng DING Jian (Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 200031,China)

【机构】 中国科学院上海药物研究所；

【摘要】 <正>Salvicine是从中国药用植物红根草中提取、分离出的二萜醌化合物经修饰而得到的一个全新结构的化合物,前期研究显示出了明显的体内外抗肿瘤效应。本研究从体外抗瘤谱、对肿瘤细胞周期和凋亡发生的影响几个方面,探讨了salvicine体外抗肿瘤作用的特点及可更多还原

【Abstract】 Salvicine is a novel diterpenoid quinone compound obtained by structural modification of a natural product lead isolated from a Chinese medicinal plant Salvia prionitis Hance (Labiatae).In preliminary tests,salvicine showed high in vitro and in vivo antitomor activity.In the present study,we examined the in vitro antitomor activity of salvicine on 15 human tumor cell lines representing different histopathologies of 7 categories of human tumors especially solid tumors, its effect on cell cycle progression and apoptosis occuring of human leukemia K562 and gastric adenocarcinoma SGC-7901 cell line for further understanding the feature of action in vitro and mechanism of action of salvicine.Our results showed:The cytotoxic activities of salvicine was more potent than reference drugs vincristine(VCR) and etoposide(VP-16) on 12 human solid tumor cell lines,and on an average of IC50 value,it was over 5.4- and 4.2-fold more cytotoxic than those of VCR and VP-16,respectively.Moreover salvicine presented better activities especially against gastric and lung cancer cell lines,it was 10.8- and 7.7-fold more cytotoxic than that of VCR,9.0- and 3.2-fold than that of VP-16,respectively.These results suggest that salvicine may have relative selectivity effects against certain human solid tumor cell lines.For 3 human leukemia cell lines, salvicine was as cytotoxic as VP-16 and weaker than VCR.更多还原