【作者】 谭余庆； 霍海如； 姜廷良；

【Author】 Tan Yuqing,Huo Hairu,Jiang Tingling (Institute of Materia Madia,China Academy of Traditional Chinese Medicine,Beijing.100700)

【机构】 中国中医研究院中药研究所；

【摘要】 <正>生命活动的维持、机体内环境的稳定有赖于细胞对外界信号产生特定应答效应的一系列复杂的信号转导和调节系统。第一信使（包括激素、神经递质、细胞因子、生长因子等）与其特异受体结合后,被激活的受体通过刺激特定的效应酶或离子通道,然后通过胞浆内的第二信使(如cAMP、cGMP、IP₃、DAG、Ca²⁺)、蛋白激酶将信息传递到细胞内,进而对细胞、机体进行调节。更多还原

【Abstract】 GZT and Fr.B might significantly increase the cAMP activity in hyupothalamus in rats with inhibited gastrointestinal motility induced by atropine.Effect of GZT and Fr.B on cAMP activity was not found in rats with excited gastrointestinal motility induced by neostigamine. GZT and Fr.B might markedly antagonize the decrease of PKA activity in hypothalamus,gastric antrum and jejunum in atropinized rats.They did not antagonize the increase of PKA activity in these tissues in neostigminized rats.On the contrary,an increasing trend of the activity of PKA in the tissue appeared after oral administration of GZT and Fr.B in neostigaminized rats.更多还原