【作者】 鞠贵春； 张爱武； 黄伟； 黄杰；

【Author】 JU Guichun;ZHANG Aiwu;HUANG Wei;HUANG Jie;Chinese Medicine Materials College, Jilin Agricultural University;

【机构】 吉林农业大学中药材学院；

【摘要】 本试验以Wistar大鼠为试验对象,将20只体重200±20g的Wistar大鼠按体重和给药前血压随机分为空白组与鹿茸低、中、高剂量组,给药量分别为200mg/kg、400mg/kg、800mg/kg,空白组以等容积生理盐水灌胃。用BP-6无创血压测量仪,在给药前后对大鼠血压进行了测量,给药两周后血压分别为:(117.47±1.15)(mm Hg)、(116.61±2.29)(mm Hg)、(117.50±3.34)(mm Hg)、(115.54±2.32)(mm Hg);给药四周后血压分别为:(116.63±3.94)(mm Hg)、(116.54±2.45)(mm Hg)、(117.68±2.22)(mm Hg)、(116.74±3.24)(mm Hg),对照组与三个试验组对血压的影响差异不显著(P>0.05),每组内给药前与给药2周、4周后,血压变化不明显,差异不显著(P>0.05),在试验设计的范围内鹿茸的食用量和食用时间对大鼠的血压没有影响。更多还原

【Abstract】 20 Wistar rats weighted only 200±20 g were used as experimental animals and divided into 4 groups at random. Dosages of groups2-4were 200,400,800mg/kg respectively, while group 1 was given same amount of saline. The blood pressure was measured using a BP-6 noninvasive blood pressure measurement instruments.Blood pressure was measured before and after drug delivery,two weeks later blood pressure was:(117.47±1.15)(mm Hg),(116.61±2.29)(mm Hg),(117.50±3.34)(mm Hg),(115.54±2.32)(mm Hg)respectivel y,and four weeks later blood pressure was:(116.63±3.94)(mm Hg),(116.54±2.45)(mm Hg),(117.68±2.22)(mm Hg),(116.74±3.24)(mm Hg) respectively. The results showed that there were no significant difference between 1 group(blank) and the other three groups(P > 0.05), blood pressure had no significant difference among each group before or after drug delivery 2 weeks or 4 weeks later(P > 0.05). In conclusion, under the scope of the test design, dosage of velvet antler and time of drug delivery had no effect on the blood pressure of rats.更多还原