【作者】 苗顺东； 翁文剑； 程逵； 杜丕一； 沈鸽； 韩高荣；

【Author】 Miao Shundong,Weng Wenjian,Cheng Kui,Du Piyi,Shen Ge,Han Gaorong (Department of Materials Science and Engineering,Zhejiang University,Hangzhou 310027,China)

【机构】 浙江大学材料科学与工程系；

【摘要】 在钙磷酸盐基础上设计生物活性材料有望发展出高性能临床应用的硬组织修复材料。近年来,含锌钙磷酸盐材料能刺激骨组织生长为研究的热点。本文综述了含锌的钙磷酸盐材料研究状况,着重讨论钙磷酸盐材料中锌离子的存在状态以及掺锌后的物理化学性能。这些对于含锌钙磷酸盐材料植入后促进骨形成具有重要的影响。包括含锌钙磷酸盐材料的合成和性能,锌的生物学性能以及含锌钙磷酸盐材料在体内和体外的研究状况。更多还原

【Abstract】 Design of biomaterials based on calcium phosphate is a prospective way to develop high-performance hard tissue repairing in clinics.In recent years,zinc containing calcium phosphate biomaterial has attracted many attentions since its stimulating effect on bone formation following implantation.The intent of this article is to present a synopsis of the current understanding of zinc containing calcium phosphate.Emphasis is directed toward the existing state of zinc in calcium phosphate materials and their physiochemical properties that lead to enhanced bone formation surrounding implants in the early stage after implantation.These include:synthesize of zinc containing calcium phosphate materials and their properties,role of zinc in biology and nutrition and the performance of zinc containing calcium phosphate materials in vitro and in vivo.更多还原