【作者】 郑玲； 王利； 王达； 邓宁； 吕旭东； 段会龙；

【Author】 Ling Zheng~1,Li Wang~1,Da Wang~2,Ning Deng~(1*),Xudong Lu~1,Huilong Duan~1 (1 College of Biomedical Engineering and Instrument Science of Zhejiang University The Key Laboratory of Biomedical Engineering,Ministry of Education,Hangzhou 310027,China 2 Department of Colorectal Surgery,Sir Run Run Shaw Hospital,Zhejiang University,Hangzhou 310016,China)

【机构】 浙江大学生物医学工程与仪器科学学院； 浙江大学医学院附属邵逸夫医院；

【摘要】 为了缩小结直肠癌临床实践和实验室研究之间的鸿沟,我们构建了一个融合150例病人的临床、组学和流行病学数据的数据库。在此基础上,我们建立了结直肠癌转化研究信息平台,为临床医生、分子生物学研究人员和其他结直肠癌转化研究人员提供数据查询、集成浏览和分析等功能,促进结直肠癌基因型与表现型之间关系的研究,加速基础研究成果应用于临床实践。本论文介绍了我们目前关于临床组学数据库构建的工作,重点介绍了应用EAV-ER模型进行数据库设计,以适应生物医学数据的动态性和稀疏性。更多还原

【Abstract】 To provide an open translational research platform to narrow the gap between clinical practice and laboratory research of colorectal cancer,we construct a more comprehensive clinical omics database integrating not only clinical and omics data,but also epidemiology data from more than 150 patients.Based on this integrated database, we provide query,integrated view,and data analysis for clinical physicians,molecular biologists,and other researchers related with colorectal cancer translational research,facilitating the investigation of genotype-phenotype correlations in colorectal cancer and the application of basic research results in clinical practice.This paper presents our present work on the clinical omics database.Specifically,we apply EAV-ER model in the concept model design of this integrated database to accommodate the dynamic and sparse nature of biomedical data.更多还原