The Possible Role of Autophagy in Hypoxia-Induced Pulmonary Arterial Hypertension

【作者】 王嫱； 张缪佳；

【机构】 南京医科大学附属第一医院风湿免疫科；

【摘要】 <正>Background and Objective Pulmonary arterial hypertension is a progressive disease with unclear etiology. The hypoxia-induced damage of pulmonary arterial endothelial cells is one of its main pathogenesis.It is important to understand the intracellular signaling pathways that are involved in the damage of endothelial cells. Recent evidence suggests that apoptosis of endothelial cells plays a "trigger" role in the pathogenesis of PAH.更多还原