【作者】 陈远岭； 叶凤珍； 唐伟； 台勇； 刘家洪；

【Author】 Wenzhou Kanguing Hospital,Wenzhou 325007,China Chen Yuan-ling Ye Feng-zhen Tang Wei Tai Yon Liu Jia-hong

【机构】 温州康宁医院；

【摘要】 目的观察右佐匹克隆治疗失眠症的临床疗效与不良反应。方法 140例失眠症患者随机分为治疗组(70)例和对照组(70)例。治疗组患者每晚睡前服用右佐匹克隆3～6mg;对照组患者每晚睡前服用劳拉西泮1～2mg。连续服用4周。在服药前、服药后一周末、第二周末、第四周末应用"阿森斯失眠量表(ASDR)"评定患者睡眠障碍的改善情况。应用"副反应量表(TESS)"评定药物的不良反应。结果 ASDR评分在治疗结束时,两组较基线均显著降低(P<0.01);研究组和对照组的有效率分别为81.4%和78.6%,两组比较无显著性差异(P>0.05)。但研究组患者的起效时间较对照组快,总的睡眠质量更好。研究组不良反应发生率低于对照组(P<0.01)。结论右佐匹克隆治疗失眠症患者疗效好,且不良反应少,是一种治疗失眠症安全而有效的新药。更多还原

【Abstract】 Objective To evaluate the efficacy and safety of dexzopiclone in the treatment of insomnia. Methods 140 patients with insomnia were randomly divided into two groups and then received dexzopiclone(3-6 mg,n=70) or lorazepam(1-2mg,n=70) daily for 4 weeks.They were assessed by Asens sleep dysfunction rating(ASDR) and treatment emergent symptoms scale(TESS) before and after 1,2 and 4 weeks treatment.Results Compared with the baseline assessment,both treatment group showed significant improvement of sleeping quality with the efficacy rate of 81.4%(dexzopiclone group) and 78.6%(lorazepam group) respectively at the 4 weeks.There were no statistical differences in the efficacy rate for the two group(P>0.05),but the dexzopiclone group has the more faster efficacy and more lower incidence of adverse events than lorazepam group(P<0.01). Conclusion Dexzopiclone is effective and safe in the treatment of insomnia.更多还原