【作者】 陈松华； 王晓萌； 柳正卫； 何海波； 陈彬； 黄玉；

【Author】 Chen Songhua Wang XiaoMeng Liu Zhengwei He Haibo ChenBin HuangYu Zhejiang Provincial Centre for Disease Control and Prevention

【机构】 浙江省疾病预防控制中心；

【摘要】 目的:通过对肺结核病耐药状况和耐药趋势的调查研究,掌握我省目前主要二线抗结核药的耐药状况,为耐药结核病疫情控制提供科学依据。方法:在全省随机抽取30个县区作为样本县,将选例期间发现的涂阳病例纳入耐药监测。结果:在耐多药(MDR)病例中各种二线抗结核药物的耐药率卡那霉素(K)9.62%,卷曲霉素(CPM)11.54%,丁胺卡那霉素(AK)7.69%,环丝氨酸(CS)5.77%,氧氟沙星(OFLX)28.85%,对氨基水杨酸(PAS)32.69%。MDR病例中广泛耐药结核病(XDR)耐药率3.85%。结论:调查结果显示我省的二线抗结核药物耐药状况比较严重,耐药结核病的控制面临挑战,有必要在今后的工作中进一步提高现代结核病控制策略(DOTS)执行质量,加强实验室对MDR、XDR的检测能力,完善耐药结核病诊疗管理综合体系建设。更多还原

【Abstract】 Objective:To investigate tuberculosis drug resistance and resistance trends,obtain the current situation of major second-line drug resistance in Zhejiang Province,to provide the scientific basis for drug-resistant TB epidemic control.Method:Randomly selected 30 county sample in whole province,selected cases will be identified during the monitoring of smear-positive cases.Result:The various kinds of second-line drug resistance rate in MDR cases were K9.62%,CPM11.54%,AK7.69%,CS5.77%,OFLX28.85%,PAS32.69%The XDR rate of MDR cases was 3.85%.Conclusion:The survey results show that second-line drug resistance in Zhejiang province was serious,in order to control drug-resistant TB epidemic,we should further improve the quality of DOTS implementation in our future work,strengthen the MDR,XDR detection capability.更多还原