【作者】 俞忠明； 高家鉴；

【Author】 YU Zhong-ming,GAO Jia-jian(Zhejiang Acadamy of Chinese Traditional Medicine,Hangzhou,310007)

【机构】 浙江省中医药研究院；

【摘要】 目的:为了考察祛癜复色软膏配方药材超临界CO₂流体萃取工艺的研究。方法:对处方中主要药材补骨脂、白芷、独活采用超临CO₂流体萃取得到中间体,以补骨脂素、异补骨脂素和欧前胡素及萃取物总量为指标,采用综合评分办法,以萃取压力、温度、CO₂流量、萃取时间为因素,各设4水平,作L₁₆（4⁴）的正交试验,进行工艺优选,并对优选工艺进行重复和中试试验。结果:采用该工艺可使指标成分萃得率达到70—85%之间,且可节省大量的溶剂和能源,有利环保,并有效地保持有效成分的活性。结论:祛癜复色软膏中配方药材采用超临界CO₂流体萃取工艺是可行的。更多还原

【Abstract】 AIM:To inspect the Process of CO₂ Supercritical Fluid Extraction in the Prescription medicine of Qudianfuse Ointment.Methods:prescription medicines in the main Psoralen,Angelica,Angelicae Biseratae CO₂ Supercritical Fluid Extraction to be intermediate to Psoralen and Isopsoralen,Imperatorin and to extract the total target score for an integrated approach to extraction pressure,temperature,CO₂ flow, the extraction time is,each level of 4,for L₁₆（4⁴）of orthogonal,selection process,And repeat the selection process and pilot-test.Results:The process will enable the component indicators were stripping rate of 70-85%,and can save a lot of solvents and energy,environmentally-friendly and effectively maintain the active ingredient.Conclusion:The Process of CO₂ Supercritical Fluid Extraction in the Prescription medicine of Qudianfuse Ointment is feasible.更多还原