节点文献
Early transcriptional response induced by benzo(a)pyrene diol epoxide in human amnion epithelial FL cells
【Author】 Xiangyun Lu§,Jimin Shao§,Hongjuan Li,Yingnian Yu~* Department of Pathology and Pathophysiology,Zhejiang University School of Medicine,Hangzhou 310058,P.R.China
【机构】 Department of Pathology and Pathophysiology,Zhejiang University School of Medicine；
【摘要】 <正>(±)-anti-benzo[a]pyrene-7,8-diol-9,10-epoxide(BPDE) is a carcinogen causing bulky-adduct DNA damage.In this study,we have investigated early transcriptional changes induced by various concentrations(0.005,0.05 and 0.5μM) of this carcinogen in human amnion epithelial FL cells using
【Key words】 (±)-anti-benzo[a]pyrene-7,8-diol-9,10-epoxide(BPDE)；
Human amnion epithelial FL cells；
Early transcriptional response；
Differential gene expression；
Oligonucleotide microarray；
Quantitative real-time RT-PCR；
【基金】 supported by grant 2002CB512901 from the National Basic Research Program of China.
- 【会议录名称】 浙江省生理科学会2008年学术年会论文汇编
- 【会议名称】浙江省生理科学会2008年学术年会
- 【会议时间】2008-11-01
- 【会议地点】中国浙江丽水
- 【分类号】R114
- 【主办单位】浙江省生理科学会