三连解毒汤抗小鼠心律失常作用研究

【作者】 傅明光； 李旻辉； 刘文滨；

【机构】 包头医学院一附院；

【摘要】 目的:观察三连解毒汤抗实验性心律失常作用。方法:将小鼠随机分为空白对照组,阳性对照利多卡因组,三连解毒汤高,中,低3个剂量组。小鼠尾静脉注射氯化钙溶液诱发小鼠心律失常,通过记录Ⅱ导心电图观察三连解毒汤对氯化钙引发的实验性心律失常作用;制备氯仿诱发小鼠室颤模型观察室颤发生率。结果:三连解毒汤对氯化钙诱发的心律失常持续时间有显著的抑制作用,而对氯仿诱发的小鼠室颤发生率无影响。结论:三连解毒汤具有对抗氯化钙引起的实验性心律失常作用。更多还原

【Abstract】 Objective:To investigate the effects of "XJI" on experimental arrhythmia cardiac electrocardiogram in mice.Methods: Arrhythmia cardiac model was induced by Calcium chloride and chloroform in mice.The changes of electrocardiogram and incidence of ventricular fibrillation were observed.Results:"XJI" could significantly improve the emergence of arrhythmia cardiac and to contract the duration of cardiac arrhythmia in mice,and showed dose dependent effect.But no influence was observed in the incidence of ventricular fibrillation in mice.Conclusion:"XJI" showed anti- arrhythmia effect which was induced by Calcium chloride.更多还原