【作者】 翟华强； 贺声； 袁园； 沈燕华； 郑虎占； 欧敏；

【Author】 ZHAI Hua-qiang~1,He Sheng~2,Shen Yan-hua~2,Yuan Yuan~1,Ou Ming~2 (1 School of Chinese PAHarmacy,Beijing University of Chinese Medicine,Beijing 100102;2 Naval General Hospital,Beijing 100037)

【机构】 北京中医药大学中药学院； 海军总医院；

【摘要】 目的:观察益肺活血颗粒对CPHD家兔肺动脉压力的影响,探讨其改善PAH的作用机制。方法:采用0.7%FeCl₃溶液耳缘静脉注射造模方法建立CPHD家兔模型,随机设立正常组、模型组、卡托普利组及益肺活血颗粒组。彩色多普勒超声,检测各组家兔肺动脉内径、右室流出道、右室前壁厚、右室内径、肺动脉流速、三尖瓣流速以及观察是否有返流。结果:模型组与正常组比较,42d有显著性差异（P<0.01）;62d,益肺活血颗粒组与模型组比较,在右室内径、右室流出道、三尖瓣流速有显著性差异（P<0.05）。结论:益肺活血颗粒能缩小右室内径、降低右室流出道、减慢三尖瓣流速,改善CPHD家兔肺动脉压力。更多还原

【Abstract】 Objective To study the influence of YFHX on pulmonary pypertension pathology in the chronic pulmonary heart disease（CPHD） in rabbits.Methods A total of 12 rabbits were randomly divided into 4 groups（normal group,model group,the captopril group,YFHX group）,each group 3,the rabbits in model group,the captopril group and YFHX group were modeled using particles 0.7%FeCl₃ solution by ear vein injection,a total of 42 days,the rabbits in the captopril group and YFHX group were given captopril and YFHX,a total of 20 days,to observe and compare pulmonary vascular injury pathology of rabbits.Results Compared with the normal group,the model group reflect structural changes in the heart:pulmonary artery diameter,right ventricular outflow tract,right ventricular front wall thickness and right ventricular track,rabbits which have been modeled,showed significant difference when contrast their own at 0d and 42d（P<0.01）,Chinese medicine treatment group are different with the model group on the indicators:right ventricular outflow tract,tricuspid velocity（P<0.05）.Conclusions YFHX can treat the model of CPHD in tabbits,by reducing the blood vessels to narrow,inhibition of membrane thickening,YFHX was able to inhibit the vascular injury caused by FeCl₃,and it has a certain effect.更多还原