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丹参多酚酸口腔崩解片制剂处方的研究
Study on the formulation of Salvianolic Acid Orally Disintegrating Tablets
【作者】 周毅生; 孟江; 咸银库; 廖华卫; 段芳; 刘林;
【机构】 广东药学院中药学院;
【摘要】 目的对丹参多酚酸口腔崩解片的制剂处方和制备工艺进行研究。方法以口腔崩解片的崩解时限为指标,采用正交设计试验对处方进行优化。结果按优选处方制得的丹参多酚酸口腔崩解片能在23.5s内崩解完全,口感良好。结论按优选处方制得的丹参多酚酸口腔崩解片,达到了设计要求,且制备工艺简单、方便。
【Abstract】 Objective To study the formulation of Salvianolic Acid Orally Disintegrating Tablets and preparation process.Methods Using the disintegrating time as the assessment index by orthogonal design. Results The results showed that the tablets prepared by the best formulation acheived the goal of design and easy to operate.The prepared tablets could disintegrate in 23.5s and taste good.Conclusion The selected formulation achieved the need and preparation was simiple and convenient.
【Key words】 Salvianolic Acid; Orally Disintegrating Tablets; orthogonal design; formulation;
- 【会议录名称】 2009全国中药创新与研究论坛学术论文集
- 【会议名称】2009全国中药创新与研究论坛
- 【会议时间】2009-08-22
- 【会议地点】中国山西运城
- 【分类号】R286
- 【主办单位】中华中医药学会中药制剂分会