【作者】 扈晓宇； 吴疆； 李运东； 钟森； 刘光伟；

【Author】 HU Xiao-yu~1,Li Hui~1,Li Yundong~2,WU Jiang~3,ZHONG Seng~1,LIU Guang-Wei~4. 1 Infection Department of ChenDu Chinese Tranditional Medicine University Attachment hospital ChenDu610072,China 2 Hepatologic Department of ShangHai SuGuang Hospital, 3 Infection Department of SiChuan University West China Hospital 4 Infection Department of ShangHai PuTou Hospital

【机构】 成都中医药大学附属医院感染科； 四川大学华西医院感染科； 上海曙光医院肝病科； 上海普陀区中心医院感染科；

【摘要】 目的:探讨中药复方"清肝解毒方"对慢性重型肝炎的疗效,并试以MELD积分作为评估中药复方治疗慢重肝疗效及临床转归的预后指标。方法:将75例慢性重型肝炎患者随机分为2组:对照组37例给予"常规标准治疗";治疗组38例给予"常规标准治疗+清肝解毒法"(清肝解毒方:茵陈蒿、黄芩、败酱草、生大黄、制大黄、柴胡、郁金,每日1剂,水煎服)。两组均于治疗6周后进行疗效判定。结果:治疗6周后病人的肝、肾、脑以及凝血血流动力等多脏器系统功能均得到明显改善,表现在胆碱酯酶、PTA、MAP水平明显上升;胆红素、INR、肌酐、尿素氮水平和HE级别和CTP综合评分明显下降,(与对照组相比,P均<0.05),MELD预后分析显示其3个月预计死亡概率得以改善。结论:清肝解毒法可显著改善重型肝炎病人多脏器功能,提高存活率,改善MELD预后积分,有临床实用价值。更多还原

【Abstract】 objective:To study the therapeutic effectiveness of the herbal compound decoction---Qingganjiedu method with chronic severe hepatitis,and to assess clinic outcome by using MELD prognosis model.Methods:The patients with chronic severe hepatitis were divided into 2 groups randomly."The regular standard treatment"was given to the control group,while"the regular standard treatment"and"Qingganjiedu method"were used to the treatment group.(qingganjiedu decoction: Artemisia capillaris Thunb,Scutellaria baicalensis Georgi,patriniae,fresh rhubarb,prepared rhubarb,radix bupleuri,Curcuma aromatica Salisb,1 dose daily,water decoction.) effect evaluation was done 6 weeks later after the treatment.of herbal compound decoctions to chronic severe hepatitis.Results:6 weeks later after the treatment,patients’ multiple organ functions such as the liver,kidney,cerebral functions,blood clotting and hemodynamics functions were improved significantly as it’s shown in the increasing level of ACHE,PTA and MAP,the decreasing level of BIL,INR,Cr and BUN as well as the decreasing of HE grade and CTP score.(Compared with the control group,P was less than 0.05 in each group.) MELD prognosis analysis shows that the estimated morality in 3 months has dropped from 100%to 76%-83% after the treatment.The actual three-month survival rate was 32%。Conclusion:Qinganjiedu method could improve the multiple organ functions of patients with chronic severe hepatitis,increase survival rate as well as prognosis score,so it has practical value in clinical application.更多还原