活血培元法治疗对艾滋病患者T淋巴细胞功能的影响

【作者】 刘水腾； 童新灯； 黄华； 聂广； 周伯平；

【机构】 深圳市东湖医院； 湖北中医学院；

【摘要】 目的研究活血培元法治疗对艾滋病患者T淋巴细胞功能的影响。方法筛选已经开始服用抗逆转录病毒药物的HIV/AIDS成年患者24例,且病毒载量<500 coPies/ml,随机分成两组,一组加用东研Ⅰ号颗粒(中成药)和安慰剂对照,观察患者0、12、24周后的临床症状体征、T淋巴细胞亚群、血清HIV病毒载量以及细胞因子(IL-2、IL-4、IL-10、INF-γ)的变化。结果分析中药组与对照组0、12、24周后症状体征积分两组存在明显差异(P<0.05);T细胞亚群CD4+T细胞绝对计数也有明显差异(P<0.05);细胞因子两组均无明显差异(P>0.05)。两组病毒载量始终均为<500 coPies/ml。结论中药活血陪元法(东研Ⅰ号颗粒)能有效改善HIV/AIDS患者的临床症状及体征,提高患者的CD4+T细胞绝对计数,协助抗逆转录病毒药物控制病毒载量,但未发现对患者T细胞功能的部分细胞因子有显著影响。更多还原

【Abstract】 Objective:To study the effects of the huoxuePeiyuan PrinciPle on immunologic reconstitution of AIDS Patients.Method:twenty-four AIDS adult Patients were screened and divided into two grouPs at random who have been taking the anti-retrovirus drugs and whose HIV load<500 copies/ml.The two groups were added respectively the granules(Chinese traditional medicine)and the Placebo as a control.The Patients’clinical symptoms,physical signs and detect T lymphocyte subgroup,the virus load cytokines(IL-2、IL-4、IL-10、INF-γ)in serum at the beginning and 12、24 weeks later were observed.Result:By analyzing the clinic data at first and 12,24 weeks later,the the granules grouP and the control group,the cumulative scores of clinical symptoms and physical signs at the same time the CD4+T lymphocyte absolute counting display conspicuous differences(P<0.05), but the cytokines of IL-2、IL-4、IL-10、INF-γare on differences(P>0.05),the HIV loads of all patients were<500 copies/ml all along.Conclusion:the huoxuePeiyuan PrinciPle of the granules could effectively improve clinical symptoms,physical signs of HIV/AIDS patients,elevate CD4+T absolute counting,assist the anti-retrovirus drugs to inhibit the virus load,but it couldn’t obviously effect the cytokines of the HIV/AIDS atients.更多还原