New Insights into Pathogenic Leptospira Interrogans Genomic Constitution and Genetic Transformation Systems Establishment

【作者】 朱威南； 王金； 朱泳璋； 唐标； 张云怡； 何平； 张彦； 刘伯玉； 秦金红； 赵国屏； 郭晓奎；

【Author】 Shanghai Jiao Tong University School of Medicine;Shanghai Institute for Biological Sciences,Chinese Academy of Sciences;School of Life Sciences,Fudan University;

【机构】 Shanghai Jiao Tong University School of Medicine； Shanghai Institute for Biological Sciences,Chinese Academy of Sciences； School of Life Sciences,Fudan University；

【摘要】 <正>Background Based on dozens of complete genomic sequences of pathogenic Leptospira interrogans available so far,neither plasmids nor biologically active prophages have ever been identified,in which,merely two chromosomes are universally identified.Results We discovered,in this study,three extrachromosomal replicons designated Icp1(54,986bp),Icp2(56,757 bp),and Icp3(65,732 bp)in L.interrogans serovar Linhai str.56609 through更多还原