Associations between Brain-derived Neurotrophic Factor Gene rs6265 Polymorphisms and Cognitive Function and Psychopathology in Schizophrenic Patients:a Case Control Study

【作者】 翟金国； 陈敏； 张秋梅； 李君； 王克勤； 苏中华； 李武； 李雪梅；

【Author】 1 School of Mental Health,Jining Medical University 2 State Key Laboratory of Cognitive Neuroscience and Learning,Beijing Normal University 3 Department of Psychiatry,Second Affiliated Hospital, Jining Medical University

【机构】 School of Mental Health,Jining Medical University； State Key Laboratory of Cognitive Neuroscience and Learning,Beijing Normal University； Department of Psychiatry,Second Affiliated Hospital,Jining Medical University；

【摘要】 <正>Objective To explore the association between BDNF gene polymorphisms and cognitive function and psychopathology in Schizophrenia. Methods 224 schizophrenic patients and 220 controls were examined with polymerase chain reaction(PCR) to determine genotype and allele of BDNF gene rs6265.Clinical symptoms were assessed with PANSS.Cognitive function was assessed with Wisconsion card sorting test更多还原