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A novel population of single cell-derived OCT4~+ stem cells showed increased proliferation and differentiation under hypoxic conditions

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【作者】 张少衡赵岚孙爱军邹云增葛均波

【机构】 复旦大学附属中山医院上海市心血管病研究所

【摘要】 <正>Objective The transcription factor of octamer binding transcription factor 4(Oct4) is considered a main regulator of embryonic stem cell pluripotency and self-renewal capaCIties.Methods By means of FACS,limit-dilution culture,and embryonic stem cell culture conditions,we clonally purified a population stem cell from mouse bone marrow mesenchymal stem cells(MSC).Results These single cell-derived selected MSCs(sMSC) showed homogeneous morphology with normal proliferation and an undifferentiated

  • 【会议录名称】 中华医学会第11次心血管病学术会议论文摘要集
  • 【会议名称】中华医学会第11次心血管病学术会议
  • 【会议时间】2009-06-11
  • 【会议地点】中国辽宁大连
  • 【分类号】R329
  • 【主办单位】中华医学会心血管病学分会
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